GYY mice (expressing enhanced yellow fluorescent protein in alpha-cells) and NMRI mice were used. The Pancreas The main function of the pancreas, a gland attached to the intestine, is to control blood glucose levels. However, the process is transitory, and the beta cells eventually shift into yet another type of cell, the study found. Intraperitoneal delivery of 0.5 microg glucagon/h in PC2(-/-) mice resulted in the normalization of blood glucose concentrations. Aiming to overcome these complications, the in vitro generation of pancreatic beta cells from stem or progenitor cells appears as a promising alternative. There is good reason to believe that glucagon release, like insulin release, is influenced by physiological α-cell electrical activity and Ca2+ influx and fundamentally resembles the excitation-secretion coupling seen in many secretory cell types (9). Functional changes in insulin secretion are described in a separate section.
The higher proportion of alpha to beta