Background. New research has discovered that diabetes–or insulin resistance–in aged, lean mice has a different cellular cause than the diabetes that results from weight gain (type 2). Vascular endothelial growth factor (VEGF) has been implicated as playing an important role in the pathogenesis of both neovascular AMD and DME. The more severe of the two mutations, called R1788W, is carried by nearly one million Americans. Recent evidence indicates that the target of rapamycin signaling pathway is involved in cellular senescence and organismal aging. Elderly were more likely to develop a postoperative complication when they had diabetes, a cardiovascular disease or received anticoagulation therapy. The relationship of exudative macular degeneration to diabetes in older men, but not women, may be a result of chance.
2) Prevalence of ARM was even lower in diabetic patients presenting diabetic retinopathy, whether or not they had been treated with photocoagulation. is