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PPAR Agonists – Diabetes Self-Management

Description: The European Journal of Health Economics is a highly scientific and at the same time practical oriented journal considering the requirements of various health care systems in Europe. The treatment of hyperglycaemia has been based on lifestyle changes, diet and physical exercise, and oral antidiabetic drugs for reducing the microangiopathic complications and the high cardiovascular risk of these patients. Moreover, diabetes associated co-morbidity, including impaired vision and neuropathy may affect physical activity and postural stability with effects on bone mineral density (BMD) and fracture risk. Glitazones were introduced in 1999. While rosiglitazone and pioglitazone share some class effects with troglitazone, they have several characteristics that define them as unique agents. PPAR-alpha, the first form of PPAR to be identified, is produced primarily in the skeletal muscle and the liver, where it is involved in the body’s breakdown and transport of fatty acids