We report a 64-year-old insulin-dependent diabetic Caucasian male, on treatment with Dapsone for Dermatitis Herpetiformis, who presented with symptoms of haemolytic anaemia and right anterior ischaemic optic neuropathy (AION). NAION was diagnosed based on the following criteria: acute, painless, unilateral loss of vision, fundus features consistent with NAION and exclusion of other possible causes. The comprehensive case-control multivariate analysis revealed that only diabetes (odds ratio = 5.0, 95% confidence interval = 1.4-17.3, P = .01) was a significant risk factor. Funnel Plot, Begg’s and Egger’s linear regression test were applied to evaluate publication bias. Hypertensive Retinopathy – caused by hypertension. We found an increased prevalence of a G/T polymorphism of the ET-1 gene in patients with NAION. Both had experienced NAION in both eyes with recurrent episodes.
The optimal frequency of ophthalmological assessment for children older than eight years