Since phenformin’s introduction into clinical medicine, a total of 552 cases of lactic acidosis have been reported in patients taking this hypoglycemic agent. Although increased rates of thiamine deficiency have been described in diabetic outpatients, this phenomenon has not been studied in relation to diabetic ketoacidosis (DKA). cardiac and pulmonary disease, surgery) are contraindications to the use of metformin. To assess the incidence of fatal and nonfatal lactic acidosis with metformin use compared to placebo and other glucose-lowering treatments in patients with type 2 diabetes mellitus. He was short of breath at rest, with oxygen saturation of 84% on air, and had a Glasgow Coma Score of 13/15. This study is a matched case-control analysis concerning the type 2 diabetes population from Grenoble Hospital University. Do not exercise for several hours before the test.
Pooled data from 347 comparative trials and cohort studies revealed no cases of fatal or nonfatal lactic