Periodontal disease is the result of a complex interplay of bacterial infection and host responses, and is often modified by various systemic diseases such as diabetes mellitus. Circulation. Nomenclature is critical to this discussion, so the definition of inflammation bears repeating here. Gastroenterology 2008;135:100-10 (159 citations). To make the discovery, the team discovered the first potent, selective and orally bioavailable small molecule antagonists of PAR2 and characterized their functional responses in inflammatory cellular and animal models. Based on preliminary data, Kant found that the activation of Mitogen Kinase Kinase 4 (MKK4), a regulatory protein that controls pro-inflammatory cytokine production, is a prerequisite for high fat diet induced-insulin resistance in animal models. As time passes, this infection can move into the pelvic organs.
Experts say when inflammation becomes chronic it can damage heart valves and brain cells, trigger strokes, and promote resistance