Seventeen diabetic patients suffering from chronic neuropathic ulcer of the plantar surface of the foot entered a pilot, randomized, double-blind study comparing local application of bFGF with placebo. It is recognised that plantar shear and shear-time integral magnitudes are also contributory factors . Diabetic angiopathy though is responsible for majority of cases of foot ulcers; diabetic neuropathy is almost equally responsible for these problems. Therapies that promote rapid and complete healing and reduce the need for expensive surgical procedures impact these costs substantially. Finding the main etiology of a diabetic ulcer is very important and the first thing to be done before treatment. Diabetic wound care requires a comprehensive approach that includes strategies for reducing infection risks and managing pain, which requires knowledge of the dressings used to treat diabetic ulcers. Neuropathic ulceration is a significant cause of morbidity in patients with NIDDM.