Considerable evidence implicates impaired nitric oxide (NO) generation in the pathogenesis of diabetic neuropathic pain. But according to new research from France, injections of botulinum toxin A, commonly known by the brand name Botox, may be able to reduce pain from peripheral neuropathy. Patients included were ≥18 years on the date of first DPN prescription: tricyclic antidepressant, opioids, duloxetine, gabapentin, pregabalin, or lidocaine. A study of 181 patients was carried out by researchers from the University of Rome Tor Vergata. Probabilities and utilities were derived from the published literature. In this clinical trial, g-ER was dosed as either a single dose in the evening or as an asymmetrically divided dose regimen with the larger dose in the evening. An independent person not involved in the allocation process will be responsible for distribution of the treatments and placebos.
To determine whether SCS can control neuropathy pain over the longer term, researchers