We hypothesized that apoptosis is a downstream event in erectile dysfunction, and pro-apoptotic (Bak and Bax) and anti-apoptotic (Bcl-2 and Bcl-x) factors are involved in the etiology of diabetes induced erectile dysfunction. It is more severe and resistant to therapy than in male patients with normal glucoregulation. With the exception of middle-aged hypertensives (45-64 years) and elderly diabetic-hypertensives (> or = 65 years), no significant age- and gender-related differences were observed regarding the prescription of thiazide diuretics. The estimated high prevalence rate of sexual dysfunction among the diabetic group (89.2%) was significantly greater than the hypertensive group (43.6%), and the apparently healthy group (16.7%). Age, BMI, duration of diabetes, and the presence of coronary artery disease, nephropathy, and retinopathy had negative effects on FSD. However, in a multivariate analysis, only depression (P = 0.004) and marital status (P = 0.003) were significant
A glucosamine-like dietary supplement has been found to suppress the damaging autoimmune response seen in multiple sclerosis and type-1 diabetes mellitus, according to University of California, Irvine health sciences researchers. In studies on mice, Dr. Davis has certification through the International Fitness Professionals Association as a personal trainer. Streptozotocin and glucosamine co-treatment increased OGlcNAcylated proteomic patterns as assessed by immunoblotting, and these increases in nuclear and cytoplasmic protein O-GlcNAcylations were accompanied by impaired insulin secretion and enhanced apoptosis in pancreatic beta cells. The research team noted in the study that the effects of glucosamine on metabolism and protection from type 2 diabetes are similar to being on a low carb diet, yet without the need to restrict dietary carbohydrate intake. Glucosamine or placebo treatment for 6 weeks was followed by a 1-week washout and crossover to the other arm. It
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However, their clinical utility is limited by less