Nerve conduction block using high-intensity focused ultrasound (HIFU) has been conducted with nerves of mixed fibres in normal animal models. Vascular mural thickening averaged 18.9 +/- 9.9 micron2 in diabetic capillaries (n = 11) vs. Densities of innervation were quantitated with fluorescence microscopy. We used this procedure on a population of normal and diabetic subjects, and propose it as a new tool to study cutaneous autonomic nerves. NCV, NBF and Na,K-ATPase activity in RBCs and in sciatic nerves were significantly decreased in diabetic rats. Immunoblot analysis showed a delay in the degradation of neurofilaments (NFs) in DM during WD. Knocking out these nerves apparently prevented the mice from developing diabetes; they didn’t even experience inflammation of the beta cells (one of the early signs of Type 1 diabetes).
Your diabetes doctor—an endocrinologist—should monitor you for signs of nerve damage at every checkup.