The transcription factor Pax4 plays a critical role in the determination of α- versus β-cell lineage during endocrine pancreas development. The endocrine pancreas is unable to provide sufficient insulin to fulfill the needs of the organism. 6 x 10(7) AtT20MtIns-1.4 cells were implanted subcutaneously into streptozotocin-diabetic mice immunosuppressed with cyclosporin A. Over a five-year period, the JDRF-W.W. Wide-ranging clinical applications include haemophilia, chronic anaemia, growth hormone deficiency and diabetes. Adenoviruses carrying the -galactosidase (-gal) gene were injected into the pancreatic–duodenal vein and the clamp was released 10 min later. “The delayed response in animals carrying SIA doesn’t seem to be a problem because the final glucose levels are the same in healthy and diabetic animals, and there do not seem to be any side effects,” says Yoon.
These findings were associated with suppression of renal TGF-beta1 and mesangial