↵*Correspondence to: Petter Bjornstad, MD, Children’s Hospital Colorado, University of Colorado, Denver, 13123 East 16th Ave, B265, Aurora, CO 80045. Lower circulating level is a risk factor. Our data, obtained from a case-control study of nondiabetic women and women with gestational diabetes mellitus (GDM), further support the role of adiponectin in insulin resistance. Study design. Diabetes was defined as fasting serum glucose greater than 126 mg/dL or taking medication. Eighteen subjects with normal glucose tolerance (NGT) developed diabetes, and 709 remained NGT at the 5-year follow-up examinations. Sarpogrelate hydrochloride is a serotonin 2A receptor antagonist and is clinically used for the cutaneous ulcer and ischemic change resulting from the arteriosclerosis.
The mean (SD) age of the patients was 13.35 (2.83) years, range (7 – 17.41 years). The mean baseline adiponectin level was lower in the diabetic subjects than in the nondiabetic subjects (11.3 +/- 5.5