Individuals living with diabetes who use insulin injections or take certain oral antidiabetic drugs know that they must watch out for hypoglycemia. The authors of the study found that symptomatic hypoglycemia in T2DM patients is associated with an increased risk of CVE and lower life expectancy. The findings in these patients were compared to normal control subjects and to weight- and disease-matched patient controls. Insulin is the chemical that causes cells to absorb glucose from the blood and hence regulate the blood glucose level. The mechanisms implicated in selective damage are not completely understood but many factors have been identified including excitotoxicity, oxidative stress, zinc release, PARP-1 activation and mitochondrial dysfunction. Hypoglycemia is a condition characterized by a glucose (blood sugar) level that is too low to effectively fuel the body’s blood cells. Over time, high blood glucose levels may damage the eyes, kidneys, nerves or heart.