Tag «adult onset diabetes type 1»

Diabetes takes ‘frightening’ toll on the under-40s

Since its deorphanization in 2003 (1,2), the fatty acid receptor GPR40 (FFAR1/FFA1) has drawn considerable attention as a potential therapeutic target for type 2 diabetes. Now, a study published online today in Diabetes Care by researchers at the University of North Carolina School of Medicine, Elcelyx Therapeutics, and other leading endocrinologists provides strong evidence that metformin’s primary effect occurs in the gut, not the bloodstream. Clinicians should offer or refer patients with abnormal blood glucose to intensive behavioral counseling interventions to promote healthful diet and physical activity according to the statement, which was released online  and published in the Annals of Internal Medicine. 40.6 million diabetes prescription items were dispensed in the community; a 6.1 per cent (2.3 million items) rise on 2010/11 and a 49.9 per cent (13.5 million items) rise on 2005/06. V-Go works with no electronics, batteries, infusion sets, or programming

Effect of Conjugated Linoleic Acid Alone and in Conjunction With Vitamin E in Patients With

Even in individuals who are unwilling to make prudent changes in their diets and sedentary habits, the administration of certain nutrients and/or drugs may help to prevent or postpone the onset of type 2 diabetes. Dairy products and beef are the major and most prominent source of Conjugated Linoleic Acid. Studies investigating the mechanisms by which CLA operates at the cellular level show that the primary targets for CLA are members of the nuclear receptor family, particularly the lipostat transcription factors peroxisome proliferator-activated receptor alpha (PPARalpha), PPARgamma, sterol regulatory element-binding protein 1c, and liver X receptor alpha. While some of the changes reported are consistent with an improved lipid profile, declines in HDL and increases in lipoprotein (a) have also been observed in some subjects. The information presented by Healthnotes is for informational purposes only. Results: CLA supplementation significantly increased fasting glucose concentrations (6.3%; P < 0.05) and reduced insulin sensitivity as measured by homeostasis model assessment, oral glucose insulin sensitivity, and the insulin sensitivity index (composite) (P = 0.05). Meat from grass-grazing livestock has half the saturated fat as that from animals fed chemically altered grains. Some clinical evidence suggests that conjugated linoleic acid (CLA) enhances the blood pressure-lowering effects of ramipril (45569). Suggestions of possible deleterious effects in man due to an increase in oxidative lipid products (isoprostanes) with trans-10, cis-12 CLA ingestion require substantiation. CONCLUSIONS: These results indicate that CLA supplementation for 4 weeks in obese men with the metabolic syndrome may decrease abdominal fat, without concomitant effects on overall obesity or other cardiovascular risk factors. When CLA is driving fat out of fat tissue, the fat tends to end up in the liver or in muscles.


Feel free to agree or disagree/critique. Type I diabetes is an autoimmune disease, in which the immune system attacks the beta cells of the pancreas. The study design is illustrated in Figure 1 . Xenotransplantation, 2009. Some people with diabetes and renal failure have a kidney transplant without a pancreas transplant, but most go in for both, says endocrinologist Sue Kirkman, MD, professor of medicine at the University of North Carolina–Chapel Hill. Pancreatic islets of diabetic patients can be infiltrated, destroyed, or dysfunctional, which renders them unable to produce insulin. The consequences of these converging epidemics are likely to be substantial.

Unlike the North American centers, the European centers concentrated their efforts on islet after kidney and simultaneous islet kidney transplantation. Immunosuppressive regimens used in transplant patients have side effects whose frequency and severity restrict their use to patients who have serious progressive complications

Dad’s ingenious solution to disguising daughter’s Type 1 Diabetes pump

t:connect Insulin Pump Software: In 2013, I was invited for a sneak peak of Tandem Diabetes unveiling of the software that goes with the t:slim insulin pump. As the  first FDA-cleared touchscreen insulin pump, it is no ordinary medical device. Maybe you’ve hidden it in a boot, or in your bra. The rate is programmed as unit(s) per half hour or per hour. We also take it off if he is playing football as well, because it could get damaged. The patient programs the device to inject additional insulin right before a meal or snack based on the amount of carbohydrates about to be consumed. Being diagnosed at only 16 months old she knows nothing different that this disease and to be attached to her pump.

Before being introduced, it is recommended that you monitor your sugars about four times a day or more. || Insulin on Board (IOB) amounts apply only if the feature has been activated on your pump and you are using either the ezBG or ezCarb feature to calculate a suggested bolus

Self-monitoring and blood sugar control

Most blood glucose meters are either pretty basic and inexpensive or offer lots of features at considerable cost. Never buy a meter. For less frequent testers, or for those who have to buy their own test strips, the cost of test strips used by the meter may be one of your main considerations. Checking your sugar also helps you to see how changes in your treatment can affect your control. A later model replaced the color chart with a needle that would indicate a more accurate range, but it was still not something most people used at home. But the FDA doesn’t set the highest possible standards, so the manufacturers of blood glucose meters naturally compete largely on the basis of price. It may also help to ask other people with diabetes about their experiences with different types of meter.

Chris Gwaltney, the managing partner of BioSense, sent me the Solus V2 for my testing and review. Blood Glucose meters follow the same business model. Size and mobility is an advantage in this

How Do I Gain Muscle?

Addison’s Disease, also known as hypoadrenocorticism, is a disorder of the adrenal gland, where it fails to produce enough of a steroid hormone called aldosterone. TBIs, however, have long been a leading cause of death and disability in the U.S., and what happens to the body’s hormone system following these injuries has become an increasingly significant public health concern. Our sophisticated diagnostic equipment, team approach and minimally invasive surgical procedures mark our program as one of the best in the country. Options for management of hyperprolactinaemia include lowering doses, switching to agents such as aripiprazole, clozapine or quetiapine, managing associated osteoporosis, carefully considering the use of dopamine receptor agonists and ruling out stress, oral contraceptive use and hypothyroidism as contributing factors. Endocrine manifestations of the rapid-onset obesity with hypoventilation, hypothalamic, autonomic dysregulation, and neural tumor syndrome