Epidermal- identified by the presence of excess melanin in the superficial layers of skin. She stated that she had first noticed these lesions when aged in her 40s. In these cases, the underlying condition must be diagnosed and treated. There was no history of fever, loose stools, steatorrhea, diabetes mellitus or tuberculosis. The incidence of adverse skin reactions, diabetes, hypertension and serum creatinine in 41 women admitting use of depigmenting agents was compared to those found in 85 women who maintained they had never used depigmenting agents. Malignant acanthosis nigricans is most commonly associated with intra-abdominal malignancies. His early work with current – involving the reactions between metals and the twitching muscles of specimen frog’s legs!
When this disease occurs spontaneously, it is likely that other diseases are present or will develop. At this junction, a diagnosis of FDE was made and all the drugs were discontinued and the patient was started on Prednisolone