Introduction. RESEARCH DESIGN AND METHODS—A total of 145 young patients with early-onset diabetes (age and age at diagnosis ≤40 years) and a family history of diabetes were studied. A parent with MODY has a 50% chance of passing on MODY to their child. (14) “Overload” may be caused by a high growth rate in fetal and early life (15), or by early-life stress, such as complicated pregnancy (16), neonatal hospitalization, or even childhood psychological stress. Absolute mortality was significantly lower in females than in males (HR 0.50 [95% CI 0.38, 0.65]), although the SMRs were similar. Later age at onset of diabetes was associated with a higher rate of having a first child among men (p = 0.04) and having a second live birth among women (p = 0.002). Annually, in 1991-2009 the proportion presenting with ketoacidosis varied between 20% and 33% (mean 25%) with no change over time.
We designed and validated a diagnostic flowchart in the attempt to improve the detection rate and