Tag «abdominal pain with diabetes»

Effects of glucocorticoids and exercise on pancreatic β-cell function and diabetes development – Beaudry –

Plasminogen activator inhibitor 1 (PAI-1) is likely to play a role in vascular disease, primarily in subjects with android obesity. In addition, it was recently reported that short-term exposure to GCs reduced the insulinotropic effects of the incretin GLP-1 (glucagon-like peptide 1). TA’s ratio of clinical efficacy to systemic effects compared with oral prednisone has not been clearly defined. diabetes mellitus, dyslipidemia, weight gain, lipodystrophy) and cardiovascular (i.e. at the Gladstone Institutes. After 11 days, these STZ-diabetic mice showed increased glucocorticoid secretion and hippocampal alterations characterized by: (1) increased glial fibrillary acidic protein-positive astrocytes as a marker reacting to neurodegeneration, (2) increased c-Jun expression marking neuronal activation, (3) reduced Ki-67 immunostaining indicating decreased cell proliferation. We further demonstrate that absence of GR in hepatocytes limits the development of hyperglycemia