Different pathophysiology of impaired glucose tolerance in first-degree relatives of individuals with type 2 diabetes

Lipid abnormalities in patients with type 2 diabetes are likely to play an important role in the development of atherogenesis. However, this is frequently not achieved. Handelsman Y, Mechanick JI, Blonde L, et al. Ketosis-prone type 2 diabetes shows a strong male predominance, stronger family history, higher age and BMI, and more severe metabolic decompensation than type 1 diabetes. For these reasons, studies on the aetiology of insulin resistance have significance, both theoretical and practical. Adjustment for obesity abolished the differences in insulin resistance but not plasma insulin responses. However, insulin resistance and the “relative” insulin deficiency, observed in patients with type 2 diabetes, are likely to play a crucial role since insulin has an important function in the regulation of lipid metabolism.

Superimposition of insulin resistance on a beta cell that cannot appropriately compensate leads to deterioration in glucose tolerance. Diabetes Care.