Diabetic Retinopathy – North Carolina Retina Associates

Purpose: : In this study we explore vitreous biomarker differences of Proliferative Diabetic Retinopathy (PDR), Nonproliferative Diabetic Retinopathy (NPDR) and non-diabetic controls. Logistic regression was performed to assess the association of these factors with age, sex, severity of retinopathy, hemoglobin A(1C), total cholesterol, creatinine, duration of diabetes, and presence of macular edema. Time-resolved decay was detected in two spectral channels (ch1: 498-560 nm, ch2: 560-720 nm) and approximated by a series of three exponential functions yielding in lifetimes (τ1 , τ2 , τ3 ), amplitudes (α1 , α2 , α3 ) and their amplitude-weighted means (τm ). In addition, the identity of the retinal neurons that are most susceptible to the hyperglycaemia associated with diabetes is unclear. The central retina area which is located between the main branches (superior and inferior arcades) of the central retinal vessels (central retinal artery and central retinal vein) is the area which can develop abnormal findings in diabetic retinopathy. Overall retinopathy progression was significantly less severe in the ticlopidine group (P = .04). The texture values of eight blocks strategically located on the tongue surface, with the additional mean of all eight blocks are used to characterize the nine tongue texture features.

SOD was significantly elevated in diabetics with non-proliferative retinopathy compared to patients without retinopathy. Background or nonproliferative diabetic retinopathy (NPDR) Nonproliferative diabetic retinopathy (NPDR) is the earliest stage of diabetic retinopathy. Vision loss may be mild to severe, but even in the worst cases, peripheral (side) vision continues to function. Your vision blurs because the macula no longer receives enough blood to work properly. Many people with diabetes have mild NPDR, which usually does not affect their vision. While some cases of severe nonproliferative or proliferative diabetic retinopathy are followed carefully, others may receive laser treatment to the side part of the retina to reduce the chance of developing severe vision loss from blood collecting in the middle cavity of the eye or from scar tissue detaching from the back wall of the eye. Proliferative diabetic retinopathy (PDR) mainly occurs when many of the blood vessels in the retina close, preventing blood flow.

In an attempt to supply blood to the area where the original vessels closed, the retina responds by growing new blood vessels. This is called neovascularization. However, these new blood vessels are abnormal and do not supply the retina with proper blood flow. If you have diabetes, early detection of diabetic retinopathy is the best protection against loss of vision. Conclusions. If the vitreous hemorrhage is small, you may see a few new, dark floaters. A very large hemorrhage might block out all vision, allowing you to perceive only light and dark.

Retinal Neovascularization is formed from new blood vessels that are extremely fragile and tend to break easily and hemorrhage throughout the eye. Severe Nonproliferative Retinopathy is the next stage of Diabetic Retinopathy. In an attempt to compensate for the lack of oxygen supply, areas of the retina send signals to stimulate the growth of new blood vessels in order to try and reestablish the supply of oxygen. Macular wrinkling can distort your vision. More severe vision loss can occur if the macula or large areas of the retina are detached. Neovascular glaucoma: if a number of retinal vessels are closed, neovascularization can occur in the iris (the colored part of the eye). In this condition, the new blood vessels may block the normal flow of fluid out of the eye.

Pressure builds up in the eye, a particularly severe condition that causes damage to the optic nerve. Your physician will evaluate your retina with a dilated eye exam and retinal imaging to determine the stage of your disease. Based on what he or she sees, you will then either need to be examined yearly, be seen more frequently, or receive treatment, which can include laser therapy, intravitreal injections, surgery or combination treatment.