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Albuminuria and neuropathy in newly detected diabetics: profile and correlation. – PubMed

The aim of this study was to assess whether or not a theory-based behaviour change intervention delivered by trained and quality-assured lifestyle facilitators can achieve and maintain improvements in physical activity, dietary change, medication adherence and smoking cessation in people with recently diagnosed type 2 diabetes. The Early Diabetes Intervention Programme (ClinicalTrials.gov NCT01470937) was a randomized study based on the hypothesis that improving postprandial glucose excursions with acarbose would slow the progression of fasting hyperglycaemia in screen-detected type 2 diabetes. Allocation was concealed from patients. Diabetes at baseline was diagnosed according to 1999 WHO criteria. Sixty incident type 2 diabetic subjects (aged 35-60 years) were recruited from St. Now, the first academic study to assess whether dogs could be reliably used to ­provide an early-warning system to monitor glycaemia control has been carried out by researchers from the University of Bristol and published in the journal PLOS ONE. In conclusion, the new ECL assay identifies disease-relevant GADA by radioassay.

Importantly, this signature was detected already before the T1D-associated autoantibodies were detected. miR-103 was highly expressed in urine across all diabetes cohorts when compared to controls. The weighted prevalence of diabetic retinopathy in screening-detected type 2 diabetes was 13.0%; 12% of participants had a mild non-proliferative diabetic retinopathy and 0.6% had a moderate non-proliferative diabetic retinopathy. Because the activation of monocytes is associated with vascular endothelial damage, high concentrations of MDMPs could indicate vascular complications in diabetes patients, especially those who have diabetes-related nephropathy. Muhlestein et al.8 reported that 61% of patients showed abnormal fasting plasma glucose (FPG) and found a significant correlation between FPG and mortality. Concurrence of diabetic neuropathy and albuminuria has been found to be significantly associated. The present study reveals that presence of neuropathy as well as nephropathy is common in newly diagnosed cases of type 2 diabetes mellitus.

Both these complications have been significantly associated with increasing age indicating the possibility of a longer duration of undetected diabetes among them. Concurrence of neuropathy and nephropathy found in this study suggests that microvascular complications go hand in hand.